Сongenital infantile fibrosarcoma with a non-canonical TPM3-NTRK1 fusion transcript: a case report and a literature review

Infantile fibrosarcoma (IFS) is a rare malignant soft tissue tumor characterized by local invasion, low rate of distant metastasis (1–13%), and manifestation during the first years life. Overall survival rates range from 89 to 94%, event-free – 81 84%. Classic IFS t(12;15)(p13;q25) translocation resulting in formation ETV6-NTRK3 fusion transcript. However, over past few years, there have been numerous reports IFS-like tumors with non-canonical genetic aberrations (BRAF, NTRK1, MET genes) whose prognosis less predictable. Here we report case congenital involvement subcutaneous fat, indolent course TPM3-NTRK1 transcript identified intradermal components different histological features. The patient’s parents gave their consent use child’s data, including photographs, for research purposes publications. literature review explores modern algorithms diagnosis treatment children, new therapies, such as tropomyosin receptor kinase inhibitors, well detecting NTRK2, NTRK3 gene rearrangements solid neoplasms general, particular.